NEPHROTIC SYNDROME Nephrotic syndrome is a kidney disorder that causes your body to pass too much protein in your urine. Nephrotic syndrome is usually caused by damage to the clusters of small blood vessels in your kidneys that filter waste and excess water from your blood. The condition causes swelling, particularly in your feet and ankles, and increases the risk of other health problems. Treatment for nephrotic syndrome includes treating the condition that's causing it and taking medications. Nephrotic syndrome can increase your risk of infections and blood clots. Your doctor might recommend medications and dietary changes to prevent complications. Symptoms Signs and symptoms of nephrotic syndrome include: 1) Severe swelling (edema), particularly around your eyes and in your ankles and feet 2) Foamy urine, a result of excess protein in your urine 3) Weight gain due to fluid retention 4) Fatigue 5) Loss of appetite